Comprehensive CIRS & Chronic Inflammation Lab Panel

Chronic Inflammatory Response Syndrome (CIRS) is a complex, multi-system illness often triggered by exposure to biotoxins such as toxic mold (water-damaged buildings), Lyme disease, and blue-green algae. Because its symptoms overlap with many other conditions, standard blood tests frequently fail to capture the underlying systemic inflammation.

Our Specialized CIRS Biomarker Panel utilizes advanced plasma and serum-based ELISA assays to evaluate immune dysregulation, vascular function, and neuroendocrine signaling. This panel bridges the gaps in complex chronic cases, providing actionable insights for both patients and healthcare practitioners.

Key Benefits:

• Precision Diagnostics: Targets specific biological pathways that standard routine lab work completely overlooks.

• Multi-System Evaluation: Assesses the interconnected breakdown between your immune system, vascular health, and hormonal balance.

• Protocol Tracking: Ideal for establishing a baseline and monitoring your progress through biotoxin illness and mold detoxification protocols (such as the Shoemaker Protocol).

Biomarkers Included & Clinical Utility:

• TGF-beta 1 (Plasma ): A crucial regulatory cytokine involved in immune system balance, autoimmunity, and tissue remodeling or fibrosis.

• VEGF (Plasma ): Measures Vascular Endothelial Growth Factor to evaluate capillary health, endothelial function, and blood/oxygen delivery to tissues.

• C4a Fragment (Plasma ): An ultra-sensitive indicator of innate immune system activation and complement pathway response, highly sensitive to mold and biotoxin exposure.

• aMSH (Plasma): Evaluates alpha-Melanocyte Stimulating Hormone, a master neuroendocrine regulator controlling inflammation, sleep architecture, melatonin production, and gut barrier permeability.

• Leptin (Plasma): Assesses metabolic signaling, energy balance, and its direct link to systemic inflammation and weight gain resistance common in CIRS.

• Osmolarity (Plasma): Measures fluid balance and hypothalamic stability, critical for evaluating anti-diuretic hormone (ADH) and hydration dysregulation.

• MMP-9 (Serum): Evaluates extracellular matrix degradation and the potential for inflammatory cells to migrate into tissues, causing deep systemic pain and physical symptoms.

Who Is This Panel For?

This panel is highly recommended for individuals suffering from unexplained chronic fatigue, cognitive dysfunction (“brain fog”), chronic pain, histories of exposure to water-damaged buildings, suspected Lyme disease, or treatment-resistant inflammatory conditions.

Note: This panel is intended to support diagnostic evaluation and therapeutic planning under the guidance of a qualified functional medicine practitioner or physician.

Biomarkers